TLL1 Antibody, HRP conjugated

Code CSB-PA023595LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TLL1 Polyclonal antibody
Uniprot No.
Target Names
TLL1
Alternative Names
ASD6 antibody; TLL antibody; TLL1 antibody; TLL1_HUMAN antibody; Tolloid like 1 antibody; Tolloid-like protein 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Tolloid-like protein 1 protein (522-643AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
Gene References into Functions
  1. Multivariate analysis showed rs17047200 AT/TT to be an independent risk factor for HCC (hazard ratio, 1.78; P = .008). PMID: 28163062
  2. This SNP [TLL1 gene ]could not be confirmed as a risk factor for CHD [coronary heart disease]in T2DM [type-2 Diabetes mellitus]patients PMID: 25233961
  3. This study identified TLL1 as a new susceptibility gene for PTSD. PMID: 23726511
  4. TLL-1 gene mutation with an insertion mutation of base A in exon 10 is common in Chinese patients with sporadic congenital heart diseases. PMID: 22883091
  5. We identified a variant in a single PPAR pathway gene, TLL1, that is associated with the extent of coronary artery disease independently of clinical predictors, specifically in patients with type 2 diabetes mellitus. PMID: 21911782
  6. Data demonstrate that TLL-1, which has intermediate activity, forms a calcium-ion dependent dimer with monomers stacked side-by-side. PMID: 20043912
  7. tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains PMID: 16507574
  8. The crystal structures of the protease domains of human BMP-1 and the closely related Tolloid-like protease 1 (TLL-1), are reported. PMID: 18824173
  9. Mutations in mammalian tolloid-like 1 gene detected in adult patients with Atrial septal defect PMID: 18830233
  10. These results indicate that the hypoxia responsive motif is directly involved in the activation of the mTll-1 transcription under hypoxic conditions. PMID: 19723501

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Involvement in disease
Atrial septal defect 6 (ASD6)
Subcellular Location
Secreted.
Protein Families
Peptidase M12A family
Database Links

HGNC: 11843

OMIM: 606742

KEGG: hsa:7092

STRING: 9606.ENSP00000061240

UniGene: Hs.106513

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